The WNBA's opening weekend features a high-profile matchup as the Chicago Sky travel to Indianapolis to face the Indiana Fever at Gainbridge Fieldhouse. This game will draw major attention with two of the biggest standout rookies from 2024 (Caitlin Clark and Angel Reese) beginning their second seasons against one another. Indiana went 3-1 against Chicago last year.

The Fever had a busy offseason and currently have the second-shortest odds to win the WNBA Finals (+350), while the Sky (+5000) have the eighth-shortest odds. Indiana enters the game as a 7.5-point favorite with the total set at 168.5 points. Tip-off is set for 2 p.m. ET Saturday on ABC and ESPN+.

Key Bets for the Game

• Caitlin Clark over 38.5 total points, assists and rebounds (+105) Clark turned in one of the most remarkable rookie seasons in recent memory last year and finished it with 40.5 points, assists and rebounds (PAR) in her last eight full regular season games. She excelled against the Sky after the Olympic break averaging 41.0 PAR over the last three matchups. Expect Clark to go off in her season debut.

• Angel Reese over 2.5 assists (-115) Reese made her name as a rebounder, leading the league with 13.1 RPG in 32.5 MPG as a starter last season. But new Sky head coach Tyler Marsh has emphasized that her versatility can go well beyond the glass. One area of growth? Playmaking. With veterans like Courtney Vandersloot, Ariel Atkins, Kia Nurse and Rebecca Allen in the mix, Chicago's offense should run more smoothly -- giving Reese more chances to create for others and go over this assist number.

• Aliyah Boston over 21.5 points and rebounds (-115) There's a lot of excitement around the Fever heading into the season and Boston is a key part of Indiana's foundation alongside Clark and Kelsey Mitchell. She holds down the frontcourt, has strong chemistry with Clark, and is an efficient scorer and solid rim protector -- establishing herself as one of the league's top rising bigs. Boston's role should continue to grow and will be on full display in a matchup with Reese and Kamilla Cardoso.

• Kamilla Cardoso over 7.5 rebounds (-170) Cardoso finished her rookie season on a strong note, grabbing at least eight rebounds in all eight of the games where she played at least 25 minutes. Cardoso averaged 9.0 RPG in four games against Boston and the Fever last year, with exactly 10 rebounds in each of their last three matchups.